mRNA technology could be possible treatment for rare diseases

By exploiting the technology used in Covid-19 vaccines, a team of scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology’s potential therapeutic use in people. ​By exploiting the technology used in Covid-19 vaccines, a team of scientists has created an effective therapy for a rare disease, …

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Feeling depressed linked to short-term increase in bodyweight

Increases in symptoms of depression are associated with a subsequent increase in bodyweight when measured one month later, new research has found. The study found that the increase was greatest among people with overweight or obesity, but found no link between generally having greater symptoms of depression and higher bodyweight. ​Increases in symptoms of depression …

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Single-cell atlas of the placenta during term labor

An atlas revealing the activity of individual placental cells during childbirth offers insight on what happens at the maternal-fetal interface during term labor, according to a new study. ​An atlas revealing the activity of individual placental cells during childbirth offers insight on what happens at the maternal-fetal interface during term labor, according to a new …

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Special brain cells react to unexpected situations

New research from the Netherlands Institute for Neuroscience shows that chandelier cells, a specific type of brain cell, become active during unexpected situations. ‘Researchers have been wondering about the functionality of these cells for a long time’. ​New research from the Netherlands Institute for Neuroscience shows that chandelier cells, a specific type of brain cell, …

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Exposure therapy addressing fear of spiders can also reduce fear of heights

Exposure therapy for a specific fear can also help reduce other fears. This is the conclusion reached by psychologists who studied 50 people with a fear of spiders and heights. Although they only treated the fear of spiders, the fear of heights was likewise reduced in the process. ​Exposure therapy for a specific fear can …

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Noninvasive technique reveals how cells’ gene expression changes over time

A new method can track changes in live cell gene expression over extended periods of time. Based on Raman spectroscopy, the method doesn’t harm cells and can be performed repeatedly. ​A new method can track changes in live cell gene expression over extended periods of time. Based on Raman spectroscopy, the method doesn’t harm cells …

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Prehistoric person with Turner syndrome identified from ancient DNA

Researchers have developed a new technique to measure the number of chromosomes in ancient genomes more precisely, using it to identify the first prehistoric person with mosaic Turner syndrome (characterized by one X chromosome instead of two [XX]), who lived about 2500 years ago. ​Researchers have developed a new technique to measure the number of …

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How ‘pioneers’ blaze the one trail that determines cell fate

A new CRISPR interference (CRISPRi) model explores how the pioneer transcription factor FOXA controls human endoderm differentiation during liver development, and how the pioneer transcription factor OCT4 influences the behavior of pluripotent stem cells. The unexpected findings could influence future organoid and cell reprogramming studies. ​A new CRISPR interference (CRISPRi) model explores how the pioneer …

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