Early detection of disease is considered positive — but what if it finds ‘too much’? While early diagnosis can improve the chances of recovery, early detection can also have unwanted side effects. After all, not everything that is found would have become life-threatening in the course of the disease. TOSYMA, the world’s largest randomized diagnostic …

Early detection of breast cancer: Study confirms the effectiveness of a new approach Read More »

Axi-cel CAR T targets the CD19 molecule on large B-cell lymphoma cells. The ZUMA-7 trial demonstrated that axi-cel reduced the risk of disease progression, the need for new therapy, or death by 60% compared to standard therapy. Despite these positive outcomes in event-free survival and overall survival, some patients did not respond well to therapy …

Researchers identify key characteristics associated with improved CAR T outcomes in large B cell lymphoma Read More »

When combined with data from tree-ring records, stalagmites can open up a unique archive to study natural climate fluctuations, a research team has demonstrated. The researchers analyzed the isotopic composition of oxygen in a stalagmite formed from calcareous water in a cave in southern Germany. In conjunction with the data acquired from tree rings, they …

Stalagmites as climate archive Read More »

In summer 2022, astronomers detected the most powerful and most distant fast radio burst (FRB) ever observed. Now, astronomers have pinpointed the extraordinary object’s birthplace — and it’s rather curious, indeed. Using images from NASA’s Hubble Space Telescope, the researchers traced the FRB back to not one galaxy but a group of at least seven …

‘Blob-like’ home of farthest-known fast radio burst is collection of seven galaxies Read More »

Human activity, from burning fossil fuels and fireplaces to the contaminated dust produced by mining, alters Earth’s atmosphere in countless ways. Records of these impacts over time are preserved in everlasting polar ice that serves as a sort of time capsule, allowing scientists and historians to link Earth’s history with that of human societies. In …

The first assessment of toxic heavy metal pollution in the Southern Hemisphere over the last 2,000 years Read More »

Sharks have persisted as powerful ocean predators for more than 400 million years. They survived five mass extinctions, diversifying into an amazing variety of forms and lifestyles. But this ancient lineage is now among the world’s most threatened species groups due to overexploitation in poorly regulated fisheries and the proliferation of wasteful finning practices. ​Sharks …

A global study reveals pathways to save threatened sharks, despite rising mortality trends Read More »