Researchers have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes the toxicity that is a common feature of similar Fischer-carbene synthetic methodologies, and was used to synthesize the scaffold of the thienamycin antibiotic in high yield. This work is an …
Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people. The antibodies — a human broadly neutralizing antibody and two antibodies isolated from previously vaccinated monkeys — target the fusion peptide, a site on an HIV surface …
HIV antibodies protect animals in proof-of-concept study Read More »
Treatment of metastatic disease is responsible for nearly one-third of the decrease in annual deaths from breast cancer from 1975 to 2019, according to a new study. Treatment of metastatic disease is responsible for nearly one-third of the decrease in annual deaths from breast cancer from 1975 to 2019, according to a new study. Treatment of …
Metastatic breast cancer treatments have aided decline in deaths Read More »
A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria. A team of scientists discovered the secrets of cell variability in …
Machine learning reveals sources of heterogeneity among cells in our bodies Read More »
Researchers have discovered a novel treatment to relieve cytokine release syndrome (CRS), a life-threatening inflammation triggered by a serious infection or severe burn. Treatment with a short-acting antibody reduces the inflammatory effects of interleukin-6, a key cytokine in CRS while avoiding the side effects associated with previous longer-acting therapies. Researchers have discovered a novel treatment …
A new targeted treatment calms the cytokine storm Read More »
A study has found that older adults who exercise with their spouse achieve lower physical activity levels than older adults without their spouse. In a study of 240 participants in Singapore aged 54 to 72 years old, the researchers also found that those who received personalized feedback on their fitness trackers were more active than …
Young adults who reported higher stress as adolescents were more likely to have high blood pressure, obesity and other cardiometabolic risk factors as adults, finds new study. Young adults who reported higher stress as adolescents were more likely to have high blood pressure, obesity and other cardiometabolic risk factors as adults, finds new study. Young adults …
Our latest study shows there are racial/ethnic and socioeconomic disparities in air pollution emissions reductions, particularly in the industry and energy generation sectors. The findings provide a national investigation of air pollution emission changes in the 40 years following the enactment of the Clean Air Act (CAA). Until now, studies have primarily focused on evaluating …
US air pollution rates on the decline but pockets of inequities remain Read More »
Astronomers have found a brown dwarf (an object more massive than Jupiter but smaller than a star) with infrared emission from methane, likely due to energy in its upper atmosphere. This is an unexpected discovery because the brown dwarf, W1935, is cold and lacks a host star; therefore, there is no obvious source for the …
NASA’s Webb finds signs of possible aurorae on isolated brown dwarf Read More »
Approximately one in three deaths in the U.S. is caused by cardiovascular disease, according to the U.S. Centers for Disease Control and Prevention. New research indicates that splitting the recommended amount of physical activity between aerobic and resistance exercise reduces cardiovascular disease risks as much as aerobic-only regimens. Approximately one in three deaths in the …