Ohio State researchers have discovered that exhausted T cells collapse under the weight of misfolded proteins, activating a destructive stress response called TexPSR. Unlike normal stress systems, TexPSR accelerates protein production, flooding the cells with toxic buildup. Blocking it restored T-cell function and improved cancer immunotherapy.
Ohio State researchers have discovered that exhausted T cells collapse under the weight of misfolded proteins, activating a destructive stress response called TexPSR. Unlike normal stress systems, TexPSR accelerates protein production, flooding the cells with toxic buildup. Blocking it restored T-cell function and improved cancer immunotherapy. Ohio State researchers have discovered that exhausted T cells collapse under the weight of misfolded proteins, activating a destructive stress response called TexPSR. Unlike normal stress systems, TexPSR accelerates protein production, flooding the cells with toxic buildup. Blocking it restored T-cell function and improved cancer immunotherapy.