A new CRISPR interference (CRISPRi) model explores how the pioneer transcription factor FOXA controls human endoderm differentiation during liver development, and how the pioneer transcription factor OCT4 influences the behavior of pluripotent stem cells. The unexpected findings could influence future organoid and cell reprogramming studies.
A new CRISPR interference (CRISPRi) model explores how the pioneer transcription factor FOXA controls human endoderm differentiation during liver development, and how the pioneer transcription factor OCT4 influences the behavior of pluripotent stem cells. The unexpected findings could influence future organoid and cell reprogramming studies. A new CRISPR interference (CRISPRi) model explores how the pioneer transcription factor FOXA controls human endoderm differentiation during liver development, and how the pioneer transcription factor OCT4 influences the behavior of pluripotent stem cells. The unexpected findings could influence future organoid and cell reprogramming studies.