Semaglutide melts fat—but may quietly strip away your strength

Semaglutide, a popular anti-obesity drug, may come with a hidden cost: significant muscle loss, especially in women and older adults. A small study found that up to 40% of weight loss from semaglutide comes from lean body mass. Alarmingly, those who consumed less protein saw even more muscle loss—potentially undermining improvements in blood sugar control.

​Semaglutide, a popular anti-obesity drug, may come with a hidden cost: significant muscle loss, especially in women and older adults. A small study found that up to 40% of weight loss from semaglutide comes from lean body mass. Alarmingly, those who consumed less protein saw even more muscle loss—potentially undermining improvements in blood sugar control. Semaglutide, a popular anti-obesity drug, may come with a hidden cost: significant muscle loss, especially in women and older adults. A small study found that up to 40% of weight loss from semaglutide comes from lean body mass. Alarmingly, those who consumed less protein saw even more muscle loss—potentially undermining improvements in blood sugar control. 

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